Producing flows in dead-end pores is not currently possible through conventional pressure-driven mechanisms. Furthermore, in practical situations inducing such flows is challenging using mechanisms like electrophoresis, since one might be interested in geologic or biological systems. How to achieve flows in dead-end pores, especially in hard-to-reach places? We will explore one potential technique: “transient diffusiophoresis”. This phenomonen has been known since 1947, but the mechanism is subtle and seldom used. This talk will focus on the mechanism of diffusiophoresis, the practical applications with dead-end pores and membranes, and possibilties for producing flows in challenging chemical environments.